Treatments
We provide quick summaries of each product with links to learn more. No deep dives — just all the bleeding options, in one place.
Von Willebrand Disease
Intravenous
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Product: Humate-P
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Average Adult Half-life: Factor VIII 12.2 hours
VWD 11 hours -
Administration: Intravenous
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First Approved in US: 1986
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Derived From Human Blood: Yes
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Derived From: Human Plasma
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Manufacturer: CSL Behring
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: VonVendi
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Average Adult Half-life: VWD 19.1-22.6 hours dependent upon dosing
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Administration: Intravenous
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First Approved in US: 2015
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: Takeda
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Manufacturer Copay Assistance: $20,000
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Product Assistance Program: Yes
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Product: Wilate
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Average Adult Half-life: 10.6 hours
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Administration: Intravenous
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First Approved in US: 2009
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Derived From Human Blood: No
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Derived From: Human Plasma
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Manufacturer: Octapharma
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: Alphanate
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Average Adult Half-life: Factor VIII 17.9 hours
VWD 7.7 hours -
Administration: Intravenous
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First Approved in US: 1978
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Derived From Human Blood: No
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Derived From: Human Plasma
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Manufacturer: GRIFOLS
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Manufacturer Copay Assistance: For previously enrolled patients only
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Product Assistance Program: Yes
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Product: Adnovate
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Average Adult Half-life: 14.7 hours
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Administration: Intravenous
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First Approved in US: 2015
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: Takeda
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Manufacturer Copay Assistance: $20,000
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Product Assistance Program: Yes
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Product: Eloctate
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Average Adult Half-life: 19.7 hours
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Administration: Intravenous
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First Approved in US: 2014
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Derived From Human Blood: No
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Derived From: Human Embryonic Kidney (HEK) cell line
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Manufacturer: Sanofi
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Manufacturer Copay Assistance: $20,000
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Product Assistance Program: Yes
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Product: Altuviiio
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Average Adult Half-life: 48.2 hours
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Administration: Intravenous
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First Approved in US: 2023
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Derived From Human Blood: No
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Derived From: Human Embryonic Kidney (HEK) cell line
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Manufacturer: Sanofi
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Manufacturer Copay Assistance: $20,000
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Product Assistance Program: Yes
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Product: Jivi
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Average Adult Half-life: 17.9 hours
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Administration: Intravenous
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First Approved in US: 2018
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Derived From Human Blood: No
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Derived From: Baby Hamster Kidney (BHK) cell line
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Manufacturer: Bayer
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Manufacturer Copay Assistance: $20,000
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Product Assistance Program: Yes
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Product: Kovaltry
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Average Adult Half-life: 14.2 hours
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Administration: Intravenous
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First Approved in US: 2016
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Derived From Human Blood: No
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Derived From: Baby Hamster Kidney (BHK) cell line
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Manufacturer: Bayer
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Manufacturer Copay Assistance: $20,000
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Product Assistance Program: Yes
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Product: Afstyla
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Average Adult Half-life: 14.2 hours
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Administration: Intravenous
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First Approved in US: 2016
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: CSL Behring
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: Nuwiq
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Average Adult Half-life: 17.1 hours
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Administration: Intravenous
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First Approved in US: 2015
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Derived From Human Blood: No
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Derived From: Human Embryonic Kidney (HEK) cell line
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Manufacturer: Octapharma
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: Novoeight
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Average Adult Half-life: 12.4 hours
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Administration: Intravenous
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First Approved in US: 2013
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: Novo Nordisk
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Manufacturer Copay Assistance: $15,000
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Product Assistance Program: Yes
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Product: Esperoct
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Average Adult Half-life: 21.7 hours
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Administration: Intravenous
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First Approved in US: 2019
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: Novo Nordisk
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Manufacturer Copay Assistance: $15,000
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Product Assistance Program: Yes
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Product: Xyntha
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Average Adult Half-life: 11.2 hours
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Administration: Intravenous
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First Approved in US: 2008
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: Pfizer
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: Koate-DVI
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Average Adult Half-life: 16.1 hours
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Administration: Intravenous
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First Approved in US: 1974
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Derived From Human Blood: Yes
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Derived From: Human Plasma
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Manufacturer: Kedrion
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Manufacturer Copay Assistance: $15,000
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Product Assistance Program: No
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Product: Humate-P
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Average Adult Half-life: 12.2 hours
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Administration: Intravenous
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First Approved in US: 1986
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Derived From Human Blood: Yes
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Derived From: Human Plasma
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Manufacturer: CSL Behring
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: Wilate
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Average Adult Half-life: 10.6 hours
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Administration: Intravenous
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First Approved in US: 2009
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Derived From Human Blood: Yes
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Derived From: Plasma
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Manufacturer: Octapharma
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: Alphanate
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Average Adult Half-life: Factor VIII 17.9 hours VWD 7.7 hours
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Administration: Intravenous
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First Approved in US: 1978
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Derived From Human Blood: Yes
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Derived From: Human Plasma
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Manufacturer: Grifols
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Manufacturer Copay Assistance: For previously enrolled patients only
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Product Assistance Program: Yes
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Hemophilia A
Intravenous
Hemophilia A
Intravenous
Intravenous
Hemophilia A
Intravenous
Sub Q
Hemlibra
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Dosing Frequency: Every 1, 2 or 4 weeks
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Administration: Subcutaneous Injection
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First Approved in US: 2017
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Inhibitor Indication: Indicated for both inhibitors and non-inhibitor patients.
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Derived From Human Blood: No
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Type: Monoclonal Antibody
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Manufacturer: Genentech
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Manufacturer Copay Assistance: $15000
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Manufacturer Product Assistance Program: Yes
Qfitlia
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Dosing Frequency: Every 1 or 2 months
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Administration: Subcutaneous Injection
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First Approve: 2025
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Inhibitor Indication: Indicated for both inhibitors and non-inhibitor patients.
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Derived From Human Blood: No
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Type: mRNA
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Manufacturer: Sanofi
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Manufacturer Copay Assistance: $20000
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Manufacturer Product Assistance Program: Yes
Alhemo
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Dosing Frequency: Daily
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Administration: Subcutaneous Injection
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First Approve: 2024
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Inhibitor Indication: Indicated for inhibitors patients only.
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Derived From Human Blood: No
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Type: Monoclonal Antibody
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Manufacturer: Novo Nordisk
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Manufacturer Copay Assistance: $15000
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Manufacturer Product Assistance Program: Yes
Hympavzi
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Dosing Frequency: Every 7 days
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Administration: Subcutaneous Injection
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First Approve: 2024
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Inhibitor Indication: Indicated for non-inhibitor patients only.
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Derived From Human Blood: No
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Type: Monoclonal Antibody
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Manufacturer: Pfizer
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Manufacturer Copay Assistance: $15000
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Manufacturer Product Assistance Program: Yes
Gene Therapy
Roctavian
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Average Factor VIII at 4 Years: 33.60%
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Administration: One time infusion
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Pre-existing antibodies to adeno-associated virus serotype 5 accessibility: Not Acceptable. Patients must test negative for adeno-associated virus serotype 5 to receive Roctavian.
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Derived From Human Blood: No
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Gene Therapy Type: Adeno-associated virus vector-based (AAV5)
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Manufacturer: BioMarin
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First Approved in US: 2023
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Manufacturer Financial Assistance Program: Yes
Hemophilia A with Inhibitors
Intravenous
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Product: Novoseven RT
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Average Adult Half-life: 2-3 hours
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Administration: Intravenous
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First Approved in US: 1999
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Derived From Human Blood: No
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Derived From: Baby Hamster Kidney (BHK) cell line
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Manufacturer: Novo Nordisk
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Manufacturer Copay Assistance: $15,000
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Product Assistance Program: Yes
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Product: SevenFACT
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Average Adult Half-life: 1.6 hours
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Administration: Intravenous
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First Approved in US: 2020
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Derived From Human Blood: No
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Derived From: Genetically Engineered Rabbit's Milk
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Manufacturer: HEMA Biologics
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: Feiba
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Average Adult Half-life: "The pharmacokinetic properties of FEIBA have not been formally studied in humans." Every 6-12 hours dosing
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Administration: Intravenous
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First Approved in US: 1986
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Derived From Human Blood: Yes
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Derived From: Human Plasma
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Manufacturer: Takeda
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Manufacturer Copay Assistance: $20,000
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Product Assistance Program: Yes
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Hemophilia B
Intravenous
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Product: Idelvion
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Average Adult Half-life: 104 hours
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Administration: Intravenous
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First Approved in US: 2016
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: CSL Behring
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: Benefix
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Average Adult Half-life: 22.4 hours
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Administration: Intravenous
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First Approved in US: 1997
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: Pfizer
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: Alprolix
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Average Adult Half-life: 86 hours
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Administration: Intravenous
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First Approved in US: 2014
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Derived From Human Blood: No
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Derived From: Human Embryonic Kidney (HEK) cell line
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Manufacturer: Sanofi
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Manufacturer Copay Assistance: $20,000
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Product Assistance Program: Yes
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Product: Ixinity
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Average Adult Half-life: 24 hours
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Administration: Intravenous
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First Approved in US: 2015
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: Medexus
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: Yes
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Product: Rebinyn
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Average Adult Half-life: 115 hours
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Administration: Intravenous
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First Approved in US: 2017
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: Novo Nordisk
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Manufacturer Copay Assistance: $15,000
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Product Assistance Program:
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Product: AlphaNine SD
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Average Adult Half-life: 21 hours
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Administration: Intravenous
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First Approved in US: 1996
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Derived From Human Blood: Yes
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Derived From: Human plasma
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Manufacturer: Grifols
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Manufacturer Copay Assistance: No annual limits
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Product Assistance Program: Yes
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Product: Profilnine
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Average Adult Half-life: 24.7 hours
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Administration: Intravenous
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First Approved in US: 1986
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Derived From Human Blood: Yes
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Derived From: Human plasma
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Manufacturer: Grifols
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Manufacturer Copay Assistance: No
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Product Assistance Program: No
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Product: Rixubis
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Average Adult Half-life: 26.7 hours
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Administration: Intravenous
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First Approved in US: 2013
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Derived From Human Blood: No
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Derived From: Chinese Hamster Ovary (CHO) cells
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Manufacturer: Takeda
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Manufacturer Copay Assistance: $20,000
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Product Assistance Program: Yes
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Sub Q
Qfitlia
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Dosing Frequency: Every 1 or 2 months
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Administration: Subcutaneous Injection
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First Approve: 2025
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Inhibitor Indication: Indicated for both inhibitors and non-inhibitor patients.
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Derived From Human Blood: No
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Type: mRNA
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Manufacturer: Sanofi
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Manufacturer Copay Assistance: $20000
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Manufacturer Product Assistance Program: Yes
Alhemo
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Dosing Frequency: Daily
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Administration: Subcutaneous Injection
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First Approve: 2024
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Inhibitor Indication: Indicated for inhibitors patients only.
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Derived From Human Blood: No
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Type: Monoclonal Antibody
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Manufacturer: Novo Nordisk
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Manufacturer Copay Assistance: $15000
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Manufacturer Product Assistance Program: Yes
Hympavzi
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Dosing Frequency: Every 7 days
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Administration: Subcutaneous Injection
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First Approve: 2024
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Inhibitor Indication: Indicated for non-inhibitor patients only.
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Derived From Human Blood: No
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Type: Monoclonal Antibody
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Manufacturer: Pfizer
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Manufacturer Copay Assistance: $15000
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Manufacturer Product Assistance Program: Yes
Gene Therapy
Hemgenix
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Product: Hemgenix
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Average Factor IX at 2 Years: 37%
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Administration: One time infusion
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Pre-existing antibodies to adeno-associated virus serotype 5 accessibility: Acceptable. Patients that test positive for adeno-associated virus serotype 5 antibodies may still be able to receive Hemgenix.
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Derived From Human Blood: No
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Gene Therapy Type: Adeno-associated virus vector-based (AAV5)
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Manufacturer: CSL Behring
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First Approved in US: 2022
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Manufacturer Financial Assistance Program: Yes
Factor X Deficiency
Intravenous
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Product: Coagadex
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Average Adult Half-life: 30.3 hours
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Administration: Intravenous
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First Approved in US: 2015
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Derived From Human Blood: Yes
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Derived From: Human Plasma
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Manufacturer: Kedrion
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Manufacturer Copay Assistance: $12,000
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Product Assistance Program: No
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Fibrin Stabilizing Factor Deficiency/Factor XIII (13) Deficiency
Intravenous
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Product: Tretten
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Average Adult Half-life: 5.1 days
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Administration: Intravenous
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First Approved in US: 2013
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Derived From Human Blood: No
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Derived From: Saccharomyces Cerevisiae
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Manufacturer: Novo Nordisk
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Manufacturer Copay Assistance: $15,000
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Product Assistance Program: Yes
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Product: Corifact
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Average Adult Half-life: 7.1 days
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Administration: Intravenous
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First Approved in US: 2011
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Derived From Human Blood: Yes
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Derived From: Human Plasma
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Manufacturer: CSL Behring
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Manufacturer Copay Assistance: No
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Product Assistance Program: Yes
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Alexander’s Disease/Factor VII (7) Deficiency
Intravenous
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Product: Novoseven RT
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Average Adult Half-life: 2-3 hours
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Administration: Intravenous
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First Approved in US: 1999
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Derived From Human Blood: No
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Derived From: Baby Hamster Kidney (BHK) cell line
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Manufacturer: Novo Nordisk
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Manufacturer Copay Assistance: $15,000
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Product Assistance Program: Yes
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Intravenous
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Product: RiaSTAP
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Average Adult Half-life: 82.3 hours
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Administration: Intravenous
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First Approved in US: 2009
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Derived From Human Blood: Yes
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Derived From: Human Plasma
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Manufacturer: CSL Behring
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Manufacturer Copay Assistance: No
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Product Assistance Program: Yes
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Product: FIBRYGA
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Average Adult Half-life: 75.9 hours
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Administration: Intravenous
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First Approved in US: 2017
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Derived From Human Blood: Yes
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Derived From: Human Plasma
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Manufacturer: Octapharma
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Manufacturer Copay Assistance: $2,500
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Product Assistance Program: Yes
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Plasminogen Deficiency
Intravenous
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Product: RYPLAZIM
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Average Adult Half-life: 34 hours
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Administration: Intravenous
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First Approved in US: 2021
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Derived From Human Blood: Yes
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Derived From: Human Plasma
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Manufacturer: Kedrion
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Manufacturer Copay Assistance: $20,000
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Product Assistance Program: No
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Acquired Thrombotic Thrombocytopenic Purpura (aTTP)
Intravenous
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Product: Cablivi
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Average Adult Half-life: "The half-life of Cablivi is concentration and target-level dependent."
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Administration: Intravenous and Subcutaneous
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First Approved in US: 2019
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Derived From Human Blood: No
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Derived From: Escherichia Coli
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Manufacturer: Sanofi
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Manufacturer Copay Assistance: $25,000
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Product Assistance Program: Yes
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